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Low Dose Naltrexone

Low dose Naltrexone (LDN) has been called a “wonder drug” for years. Its mechanism of action in the body works to boost the immune system, activating the body's own natural defences. LDN blocks opioid receptors which helps release endorphins. Low levels of endorphins are a common component in many different diseases and health conditions. LDN is an effective treatment for a wide range of cancers, auto-immune disorders such as crohns and celiac disease and neurodegenerative diseases such as ALS and MS.

LDN was first approved for use in 1984 to help opium and heroin addicts by blocking the effects of such drugs. 1 year later, a Medical Doctor by the name of Bernard Behari, found that the drug, at a much lower dose, was found to have profound effects on the body's immune system. Behari found that low doses of LDN helped his patients with HIV/AIDS, auto-immune disorders and cancer.

Diseases such as cancer or auto-immune disorders are largely triggered by a deficiency in endorphins. Low dose naltrexone works primarily by blocking opiate receptors which causes a cascade of events involving increasing the number of endorphins in the body which ultimately improves immune function. For cancer, increasing the number of opiate receptors on the tumor cell membrane can make these cells more responsive to cell death potentially causing stability in tumor size, a reduction in tumor size and in some cases remission.

Diseases LDN is effective for:


  • Bladder Cancer
  • Breast Cancer
  • Carcinoid
  • Colon & Rectal Cancer
  • Glioblastoma
  • Liver Cancer
  • Lung Cancer (Non-Small Cell)
  • Lymphocytic Leukemia (chronic)
  • Lymphoma (Hodgkin's and Non-Hodgkin's)
  • Malignant Melanoma
  • Multiple Myeloma
  • Neuroblastoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer (untreated)
  • Renal Cell Carcinoma
  • Throat Cancer
  • Uterine Cancer

Other Diseases

  • Common Colds (URI’s)
  • Emphysema (COPD)
  • HIV/AIDSAutoimmune 


  • ALS (Lou Gehrig's Disease)
  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Hereditary Spastic Paraparesis
  • Multiple Sclerosis (MS)
  • Parkinson's Disease
  • Primary Lateral Sclerosis (PLS)
  • Progressive Supranuclear Palsy
  • Transverse Myelitis

Other Autoimmune Diseases:

  • Ankylosing Spondylitis
  • Behcet's Disease
  • Celiac Disease
  • Chronic Fatigue Syndrome
  • CREST syndrome
  • Crohn's Disease
  • Dermatomyositis
  • Dystonia
  • Endometriosis
  • Fibromyalgia
  • Hashimoto’s Thyroiditis
  • Irritable Bowel Syndrome (IBS)
  • Myasthenia Gravis (MG)
  • Nephrotic Syndrome
  • Pemphigoid
  • Primary Biliary Cirrhosis
  • Psoriasis
  • Rheumatoid Arthritis
  • Sarcoidosis
  • Scleroderma
  • Sjogren’s Syndrome
  • Stiff Person Syndrome (SPS)
  • Systemic Lupus (SLE)
  • Ulcerative Colitis
  • Wegener's Granulomatosis

LDN is taken in a capsule form, usually once a day at bedtime. Adverse reactions are rare and occur in approximately 2% of people taking LDN. If side effects do occur, they most often present in the first few weeks of treatment until a tolerated maintenance dose is achieved. Side effects can include nausea and vomiting, dry mouth, nightmares, and weight loss. LDN is not an expensive drug and there are no interactions with chemotherapy and radiation therapy. 


LDNScience - Welcome to LDNscience! All the science about Low Dose Naltrexone (LDN), Opioid             Growth Factor (OGF), and related therapies. (2010). Retrieved from

Low Dose Naltrexone. (2014).  Retrieved from

McKinney, Neil. (2012). Natruopathic Oncology: An Encyclopedia Guide for Patients & Physicians         (2nd ed.). Vancouver, BC: Liason Press.